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Detectives in Washington D.C. discover a puzzling connection between two women who disappeared two decades apart; an investigation reveals a sinister secret hidden along one of the busiest stretches of interstate in the country.

Dateline NBC

The five-year investigation into the death of a retired corrections officer, who was killed by antifreeze poisoning, reveals multiple suspects.

A look at the case of con man John Meehan, including interviews with his wife and her daughter, his ex-wife, law enforcement officers, and the Los Angeles Times reporter who shined a spotlight on the story.

The FBI gets involved when a Virginia man's wife and son are kidnapped while vacationing in the Philippines, with a terrorist group demanding millions in ransom.

A matriarch's death leads to a prominent family from Texas being torn apart by decades of betrayal, greed and mistrust.

A woman's disappearance tears her young children apart; a sting operation catches an unlikely villain.

When a Pennsylvania man who was convinced his messy divorce put a target on his back is found stabbed to death, his friends and family realize he was right all along in predicting his own gruesome murder.

When detectives track down the killer of a Las Vegas cocktail waitress and mother, it becomes clear that the investigation has just begun.

A woman's story about an abduction and murder helps reopen a decades-old case that has weighed heavy on a New York town.

When a young woman is found nearly murdered in her apartment, officials wonder if it is connected to the disappearance of a young woman in nearby Denver weeks earlier.

The question of a surgeon's whereabouts remains unanswered for five years after he disappears while on vacation in the Greek Islands with his wife, leaving behind financial ruin and mounting malpractice suits from patients in the U.S.

Lead investigators and family members speak about the murder of Colorado mother Kelsey Berreth, whose disappearance made national headlines after she was last seen grocery shopping on Thanksgiving in 2018.

Two decades after a Jacksonville, Fla., woman goes missing, her son solves the mystery that haunted his childhood.

When a University of Utah athlete is found murdered on campus, investigators learn that she had reached out to the campus police for help multiple times before her death.

Identical twins find their mother's dead body in their home, located in a gated community; detectives uncover a hidden diary and clues buried in the victim's past.

A woman finds herself on the wrong side of the law after she accuses her boyfriend of rape.

A woman accused of attempting to hire a hit man to kill her husband.

As a murder victim's sisters dedicate themselves to finding the killer, an unexpected source turns the case upside down.

When a model and up-and-coming YouTube celebrity turns up dead, police question her husband in the hope he can shed some light on the situation.

When a pathologist is found murdered in his home, the investigation reveals simmering jealousies and a love triangle.

Josh Mankiewicz reports on the mysterious disappearance of a Colorado rancher, whose friends think something isn't right and spend years fighting for answers.